Chulalongkorn University Dental Journal

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The median lethal dose (LD50) of local anaesthetics in mice was determined by the method of Reed & Muench. No statistical difference (P < 0.05) was found in comparing the (LD50) of the four commonly-used local anaesthetic preparations; they were lidocaine 2%, lidocaine 2% with adrenaline 1:80,000, lidocaine 2% with noradrenaline 1:50,000 and prilocaine 3% with felypressin 0.03 IU. It is suggested therefore that, in mice, the (LD50) of these local anaesthetics are comparable. However, lidocaine 2% with noradrenaline 1:50,000 had a wider therapeutic index, therefore it could be the safest local anaesthetic among the other three drugs.



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