Chulalongkorn University Dental Journal
Publication Date
1982-01-01
Abstract
The median lethal dose (LD50) of local anaesthetics in mice was determined by the method of Reed & Muench. No statistical difference (P < 0.05) was found in comparing the (LD50) of the four commonly-used local anaesthetic preparations; they were lidocaine 2%, lidocaine 2% with adrenaline 1:80,000, lidocaine 2% with noradrenaline 1:50,000 and prilocaine 3% with felypressin 0.03 IU. It is suggested therefore that, in mice, the (LD50) of these local anaesthetics are comparable. However, lidocaine 2% with noradrenaline 1:50,000 had a wider therapeutic index, therefore it could be the safest local anaesthetic among the other three drugs.
DOI
10.58837/CHULA.CUDJ.15.1.2
First Page
9
Last Page
13
Recommended Citation
Songkittiguna, Prasert
(1982)
"Median Lethal Dose of Some Local Anaesthetic Preparations,"
Chulalongkorn University Dental Journal: Vol. 15:
Iss.
1, Article 2.
DOI: 10.58837/CHULA.CUDJ.15.1.2
Available at:
https://digital.car.chula.ac.th/cudj/vol15/iss1/2