Chulalongkorn University Dental Journal

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Diphenhydramine hydrochloride (DPH) is an antihistamine which possesses local anesthetic properties. The efficacy of DPH was tested as a local anesthetic for tooth extraction in allergic patients. The onset, duration and depth of anesthesia of DPH were less efficious than that of lidocaine. Out of 33 cases of tooth extraction using DPH, 60.6% produced profound, 27.3% satisfactory and only 12.1% produced unsatisfactory anesthesia. There was no statistically significant difference in blood pressure and heart rate before and after injection of DPH. Neither severe adverse reactions nor allergic reactions could be found in this study. The results indicated that the use of DPH as a local anesthetic alternative was safe and effective for simple tooth extraction in allergic patients.



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