Chulalongkorn Medical Journal


Background: Brugada syndrome (BrS) is a rare cardiac arrhythmic syndrome which can increase the risk of sudden cardiac death in patients without structural heart disease. BrS may affect patients’ quality of life due to long-term follow-up. Objective: To identify the quality of life and related factors in patients with BrS. Methods: Twenty-nine patients with BrS from King Chulalongkorn Memorial Hospital were recruited between August 2019 to April 2020. We collected demographic data, evaluated depression/anxiety with Thai-HADS test, and administered cognitive tests and the quality of life questionnaires (MacNew and SF-36). Descriptive and multiple linear regression were used to analyze the data. Results: There were 28 male and 1 female subjects. The average age was 45.2  13.8 years old. The result of MacNew questionnaire score was 5.6  0.8. For SF-36, the physical component score was 49.8  6.4 and mental component score was 52.9  6.3. The score of anxiety and depression from HADS was 4.4  2.9 and 3.3  3.3, respectively. For the cognitive test, the following results were observed; the Grooved Pegboard on dominant (78.4  27.9 seconds) and non-dominant (84.5  26.0 seconds), Trail A (53.7  20.7 seconds) and B (181.0 80.9 seconds), and memory tests (Word List Memory 21.0  4.4 words; recall 7.2  2.6 words; and recognition 9.6  1.0 words). From multiple regression analysis, only the anxiety score from HADS had a statistically significant impact on the quality of life. Conclusion: Most BrS patients had a moderate quality of life and anxiety was an essential predictor for quality of life in BrS patients.


Faculty of Medicine, Chulalongkorn University



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