Chulalongkorn Medical Journal


Background: Demyelinating disease is an inflammatory disease of the white matter in the brain and of the sheath that covers the nerves, optic nerves, and spinal cord, and its progression is often found to be continuously recurring and eventually develops into disability, stress, depression and anxiety. Objectives: To study the prevalence and the related factors of depression and anxiety among patients with demyelinating disease. Methods: Data were collected from a group of patients diagnosed with demyelinating disease by neurologists at the Outpatient Department, Neurology Unit, King Chulalongkorn Memorial Hospital. Depression and anxiety were assessed with the Thai Hospital Anxiety and Depression Scale (HADS). Social support, family relationships and duties, and the quality of life were assessed as independent variables. The data were analyzed for the prevalence of depression and anxiety. The univariate analysis and binary logistic regression were performed to define the related factors for depression and anxiety. Results: A total of 82 patients were consecutively recruited, 92.7% were female, and 29.3% had depression or anxiety. Social support level, family relationships and duties, and quality of life were found to be in the moderate level. The multivariate analysis revealed that the factors related to depression or anxiety were the low to medium level of quality of life (ORadj. 9.17 [95% CI 2.23, 37.73]), and personal income below than 31,889 baht per month (ORadj. 4.74 [95% CI 1.24, 18.13]). Conclusion: Almost one-third of subjects who were diagnosed with demyelinating disease suffered from either depression or anxiety. The related factors were the low quality of life and low income. Therefore, screening for depression and anxiety should be included as part of the caring process in order to increase the treatment effectiveness and quality of life for the patients.


Faculty of Medicine, Chulalongkorn University



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