Chulalongkorn Medical Journal


Background : Sepsis is a severe life-threatening condition and has a great diversity insymptoms that causes a rapid response of inflammation; as a result, itmight damage the internal organs throughout the body. Nowadays, thereis insufficient medical instrument and reliable treatment strategies thatprovide a promising diagnosis which can indicate the right sepsiscondition. The aim of this research is to improve the clinical judgment,which might lead to earlier aggressive therapeutic interventions.Objectives : To study the association and risk factors between emergency departmentpatients with sepsis.Methods : In all, 400 retrospective medical data records among emergencydepartment patients were retrieved from a variety of sources (retrospectivechart reviews). The samples were divided into culture positive andculture negative results of sepsis. After that the data were analyzedstatistically to determine the relationship and risk factors in sepsispatients.Results : This study showed that sepsis was associated with male gender,diabetes mellitus, chronic kidney diseases, alcohol dependence, lowhemoglobin level (less than 10 g/dL), albumin (less than 3.5 g/dL),lactate (more than 2.1 mmol/L), systolic blood pressure (less than 90mmHg), respectively. It was also found that the risk factors werecorresponding to diabetes mellitus (P = 0.033), chronic kidney disease(P = 0.008), low hemoglobin level (less than 10 g/dL) (P = 0.001), albumin(less than 3.5 g/dL) (P = 0.043), systolic blood pressure (less than 90mmHg) (P = 0.001).Conclusions : Sepsis is a common condition which is often seen in emergencydepartment. It is severely harmful and needs to be treated urgently. Wefound that the systolic blood pressure less than 90 mmHg was associatedwith the highest risk. Hopefully, this research could be an alternative tosupplement the diagnosis and treatment of patients with sepsis inthe future.


Faculty of Medicine, Chulalongkorn University

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