Chulalongkorn Medical Journal


Background : The EuroQoL Group’s 5-dimension, 5-level (EQ-5D-5L) is a frequentlyused questionnaire on generic health-related quality of life (HRQoL);however, studies on its psychometric properties in Thailand are rare,especially on patients with chronic diseases.Objective : To evaluate the reliability and validity of the EQ-5D-5L questionnaireon patients with chronic diseases.Research design : Cross-sectional study.Setting : King Chulalongkorn Memorial Hospital.Methods : Four hundred outpatients with chronic disease at King ChulalongkornMemorial Hospital between July 2014 and February 2015 weresurveyed. The psychometric properties of EQ-5D-5L were evaluatedin terms of practicality (administration time and ceiling effect), reliabilityand validity (known-groups validity and convergent validity).Results : The average administration time was less than 2 minutes. The ceilingeffect was 14%. Known-groups validity test was confirmed forthe following factors: gender, number of medicines taken, diseasecontrol and experiencing ADRs. EQ-5D-5L index scores had a positivecorrelation with all WHOQOL-BREF domains (rho ranged: 0.27 - 0.58)and EQ-VAS (rho = 0.49, all p < 0.01). The intra-class correlationcoefficient of EQ-5D-5L was 0.89 and weighted kappa coefficientsranged 0.44 - 0.60 in the five dimensions of EQ-5D-5L.Conclusions : EQ-5D-5L had confirmed reliability and validity on patients with chronicdisease.


Faculty of Medicine, Chulalongkorn University

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