Chulalongkorn Medical Journal


Background : Diabetes mellitus (DM) is a global epidemic and its prevalenceincreases in many region of the world. Gymnema inodorum is amedicinal plant that has been used as drug and food for a longtime in Thailand. It has hypoglycemic effect in healthy subjectswithout serious side effects. However, today there has not beenany clinical study evaluating its effect in type 2 diabetic patients.Objective : To evaluate the effect of consumption of G. inodorum tea onclinical outcomes in type 2 diabetic patients.Design : Before and after quasi-experimental study.Setting : Diabetes Clinic, Outpatient Department, Lerdsin Hospital,Bangkok.Materials and Methods : Type 2 diabetic patients voluntarily participated in the studywhich comprised of 2 consecutive phases. In the controlledphase, the patients received only prescribed drugs (week0 – week 8) and later in the treatment phase, G. inodorum teawas supplemented (week 8 – week 16). The biochemicalparameters, and nutrients and caloric intakes were evaluated atweek 0, 8, and 16.Results : The biochemical parameters including fasting blood sugar (FBS),hemoglobin A1C (HbA1C), total cholesterol (Total-C), low-densitylipoprotein cholesterol (LDL-C), high-density lipoproteincholesterol (HDL-C), triglyceride (TG), aspartate aminotransferase(AST), alanine aminotransferase (ALT), and serum creatinine(SCr) did not significantly change throughout the study. So didthe nutrient and caloric intakes.Conclusion : G. inodorum tea had no effect on blood sugar and lipid profilesin this study. It also did not affect hepatic and renal functions.


Faculty of Medicine, Chulalongkorn University

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