Chulalongkorn Medical Journal


Background : GnRH analogue can suppress serum estradiol (E2) and folliclestimulating hormone (FSH) to menopause level beforelaparoscopic enucleation of endometriotic cysts.Objective : To study the levels of E2 and FSH, and vasomotor symptomsafter GnRH analogue treatment in Thai women with endometrioticcysts.Materials and Methods : During January, 2006 - December, 2007. Sixty women diagnosedas having endometriotic cysts, aged 15 – 44 years, were recruitedinto the study. Leuprolide acetate 3.75 mg was givenintramuscularly at one month interval for 3 months. Serum levelsof E2 and FSH were tested at 0, 1, 2 and 3 months after GnRHanalogue treatments. Thai version of Greene climacteric scorewas recorded at 0, 1, 2 and 3 months.Results : The median (25th percentile, 75th percentile) of serum E2 leveldecreased significantly from the baseline (0 months: 232.3(82.0,446.2) pmol/L vs. 1 months : 18.4(0,44.9) pmol/L, 2 months:31.7(0,58.6) pmol/L, 3 months: 0(0,54.2) pmol/L). The median(25th percentile, 75th percentile) of serum FSH level decreasedsignificantly from the baseline at 1,2 and 3 months. (0 months:4.8(3.1,7.0) IU/L vs. 1 months: 2.2(1.3,3.5) IU/L, 2 months 2.8(1.8,5.2) ,3 months 3.0(2.8,4.9) IU/L). Only 8.3% of womenrequired sedative medication for vasomotor symptoms relief.The mean vasomotor symptoms scores were significantly higherthan the baseline at 2 and 3 months period (0 months: 14.5 vs.2 months: 20.0 and 3 months: 20.2). Most women hadamenorrhea at 3 months period (93.3%).Conclusion : Leuprolide acetate can suppress ovarian function after the firstmonth of injection. Most women can stand the vasomotorsymptoms. Amenorrhea was the most common menstrualpatterns at 3 months after injection.


Faculty of Medicine, Chulalongkorn University

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