Article Title

Treatment outcome of stage Ic ovarian clear cellcarcinoma compared to non-clear cell type

Authors

Y Thaweekul
R Lertkhachonsuk
N Khemapech
T Manchana
N Sirisabya
P Worasethsin
A Vasuratna
T. Tul Sittisomwong
W Termrungruanglert
D. Tresukosol

Abstract

Objective : The aim was to evaluate the treatment outcome of stage Ic clear cellcarcinoma of the ovary compared to that of non-clear cell carcinoma ofthe same stage.Methods : Having searched the tumor registry database of the Department of Obstetricsand Gynecology, King Chulalongkorn Memorial Hospital from June 1997-December 2002, we enrolled all patients with stage Ic (according to FIGOstaging criteria) clear cell carcinoma who underwent complete surgicalstaging procedure. Patients with non-clear cell adenocarcinoma of the ovarywere enrolled by the same criteria as control group. They all received postoperativeadjuvant chemotherapy with single-agent platinum based regimen.The clinical characteristics, survival time, and recurrence free survival ofboth groups were compared.Result : A total of 56 patients with stage Ic carcinoma of the ovary were recruitedinto this study. The mean age was 50 years (36 - 86 years old) in bothgroups. The median follow-up duration in the clear cell and non-clear cellgroups were 61 months (5 - 120 months) and 67 months (15 -103 months),respectively.The mean tumor diameter in the clear cell group was significantlylarger than that of the control group (12.96 vs. 9.89 cm; P-value = 0.001).Other clinical characteristics of the two groups were similar.The recurrence rate of the clear cell and non-clear cell groups were46.4% vs. 14.2% (P = 0.004) and the median time to recurrence were 10.5months (2 – 35 months) vs. 8 months (3 - 28 months), respectively. Theestimated 5-year survival for the clear cell group was significantly lower thanthat of the non-clear cell (53.6% vs. 85.7%; P-value = 0.01).Conclusion : Clear cell carcinoma of the ovary stage Ic have lower 5-year survival rateand recurrence free survival than that of the patients with non-clear cellepithelial ovarian carcinoma in the same stage. Combined chemotherapymay be needed to improve the survival of patients in stage Ic clear cellovarian cancer.

Publisher

Faculty of Medicine, Chulalongkorn University

First Page

213

Last Page

223

Recommended Citation

Thaweekul, Y; Lertkhachonsuk, R; Khemapech, N; Manchana, T; Sirisabya, N; Worasethsin, P; Vasuratna, A; Sittisomwong, T. Tul; Termrungruanglert, W; and Tresukosol, D. (2010) "Treatment outcome of stage Ic ovarian clear cellcarcinoma compared to non-clear cell type," Chulalongkorn Medical Journal: Vol. 54: Iss. 3, Article 4.
Available at: https://digital.car.chula.ac.th/clmjournal/vol54/iss3/4