Chulalongkorn University Dental Journal
Publication Date
2015-09-01
Abstract
Objective To identify single nucleotide polymorphisms (SNPs) that associated with different occlusal relationship in a group of Thai population. Materials and Methods One hundred and sixty unrelated Thai subjects†who participated†in Ramathibodi GWAS study for thyrotoxic hypokalemic periodic paralysis (TTPP) (Jongjaroenprasert, 2012) were selected. The subjects that were 20 years old and above with at least a pair of untilted permanent first molars or canines were selected from these subjects. Seventeen subjects met these criteria in our study.† Angleûs/canine classification of subjects were observed† both intraorally and from diagnostic models. Eight hundred and sixty four† human active SNPs from 28 related genes were selected from previous craniofacial studies. PERL software with Fisher exact test was used to identify the SNPs that correlated with subjectsû occlusal relationship.† Results There were 17 SNPs† from 6 genes including IGF1, HSPG2, MATN1, TGFB2, VEGF and EVC† that significantly correlated with Angleûs/canine class I occlusal relationship and† 27 SNPs from† 5 genes including IGF1, HSPG2, MATN1, TGFB1 and LTBP2 that significantly correlated with Angleûs/canine class III occlusal relationship†(P value < 0.05). These findings show that there are specific SNPs in the marker genes that correlated with Angleûs/canine class l and class III occlusal relationship. Conclusion There are significant correlations between SNPs and occlusal relationship in a Thai population subgroup. This finding leads to a†further understanding in genetic †basis of occlusal relationship.
DOI
10.58837/CHULA.CUDJ.38.3.2
First Page
185
Last Page
196
Recommended Citation
Suwanwela, Jaijam; Nitipong, Virunpat; and Ongprakobkul, Naruborn
(2015)
"Single Nucleotide Polymorphisms associated with Angleûs Class I and III Occlusal Relationship in Thais with Thyrotoxic Hypokalemic Periodic Paralysis,"
Chulalongkorn University Dental Journal: Vol. 38:
Iss.
3, Article 2.
DOI: 10.58837/CHULA.CUDJ.38.3.2
Available at:
https://digital.car.chula.ac.th/cudj/vol38/iss3/2