Role of PPAR-γ in regulating osteoclastogenesis

Authors

Wantida Sriarj

Publication Date

2013-09-01

Abstract

Osteoclasts are cells that play a crucial role in bone remodeling. These cells are derived from monocyte-macrophage lineage of hematopoietic stem cells in bone marrow. RANK-RANKL interaction has been demonstrated to be a key mechanism of osteoclastogenesis, however, recent reports revealed the novel role of peroxisome proliferator-activated receptor gamma (PPAR-γ) in the regulation of osteoclast formation. In this review, the novel function of PPAR-γ in osteoclastogenesis will be discussed. Generally, PPAR-γ has been known to play a role in metabolism of glucose and lipid, including promotes adipocyte differentiation and inhibits osteoblast differentiation. Evidence suggested that PPAR-γ could also work in accordance with RANK-RANKL system in regulating osteoclastogenesis. The novel function of PPAR-γ will not only expands our knowledge in the mechanism of osteoclastogenesis but also suggests the correlation between glucose metabolism and osteoclast formation.

DOI

10.58837/CHULA.CUDJ.36.3.6

First Page

207

Last Page

220

Recommended Citation

Sriarj, Wantida (2013) "Role of PPAR-γ in regulating osteoclastogenesis," Chulalongkorn University Dental Journal: Vol. 36: Iss. 3, Article 6.
DOI: 10.58837/CHULA.CUDJ.36.3.6
Available at: https://digital.car.chula.ac.th/cudj/vol36/iss3/6