In vitro effect of calcium hydroxide combined with chlorhexidine or stannous fluoride in reducing Candida albicans in human root canal

Authors

Siripen Wanasaengsakul
Chalermkwan Puworawan
Tipapun Setsirisombat
Karnnapat Peetiakarawach

Publication Date

2008-09-01

Abstract

Objective To evaluate the effectiveness of calcium hydroxide combined with chlorhexidine or stannous fluoride in disinfecting the Candida albicans infected human root canal in vitro. Material and Methods Antifungal effect of reagents was examined by using agar-diffusion test and counting colony forming unit of C. albicans existed in the root canal after 7 days intracanal medication. Acid-base changing of chemical agents was also examined. Results Three types of calcium hydroxide pastes could inhibit the growth of Candida on Sabouraud dextrose agar, although the statistical differences among them were not found. The pH of calcium hydroxide pastes were all more than 12. Calcium hydroxide combined with chlorhexidine or stannous fluoride could significantly reduce colony forming unit in Candida infected human root canal, whereas conventional calcium hydroxide were unable to do so. Conclusion Calcium hydroxide combined with chlorhexidine or stannous fluoride could reduce the colony forming unit of C. albicans within human root canal.

DOI

10.58837/CHULA.CUDJ.31.3.10

First Page

371

Last Page

384

Recommended Citation

Wanasaengsakul, Siripen; Puworawan, Chalermkwan; Setsirisombat, Tipapun; and Peetiakarawach, Karnnapat (2008) "In vitro effect of calcium hydroxide combined with chlorhexidine or stannous fluoride in reducing Candida albicans in human root canal," Chulalongkorn University Dental Journal: Vol. 31: Iss. 3, Article 10.
DOI: 10.58837/CHULA.CUDJ.31.3.10
Available at: https://digital.car.chula.ac.th/cudj/vol31/iss3/10