Chulalongkorn University Dental Journal
Publication Date
2005-05-01
Abstract
Objective To investigate the effect of aloe vera gel extract and exudate on the proliferation of osteoblasts isolated from the rat bone marrow stromal cells and the osteoblastic cell line MC3T3-E1. Materials and methods Cells were treated with the aloe vera gel extract and exudate at different concentrations in the serum-free media for 24 hours. After that the amount of cells were measured with the MTT assay and analyzed with One-Way Analysis of Variance. Results The aloe vera gel extract, at concentrations of 10, 20 and 50 μg/ml, significantly enhanced the proliferation of osteoblasts isolated from the rat bone marrow (p < .05). The aloe vera gel extract, at concentrations of 1, 5, 10, 20 and 50 μg/ml, significantly induced the proliferation of osteoblastic cell line MC3T3-E1 (p < .05). In contrast, the aloe vera exudate, at concentrations of 20, 40 and 60 μg/ml, significantly decreased the proliferation of osteoblasts isolated from the rat bone marrow and the osteoblastic cell line MC3T3-E1 (p < .05). Conclusion The aloe vera gel extract, 10-50 and 1-50 μg/ml, significantly induced the proliferation of the osteoblasts isolated from the rat bone marrow and the osteoblastic cell line MC3T3-E1, respectively. In contrast, the aloe vera gel exudates, 20-60 μg/ml, significantly decreased the cell number of both osteoblasts isolated from the rat bone marrow and the osteoblastic cell line MC3T3-E1.
DOI
10.58837/CHULA.CUDJ.28.2.5
First Page
127
Last Page
136
Recommended Citation
Vipismakul, Vichitra and Thunyakitpisal, Pasutha
(2005)
"Effect of aloe vera gel extract and exudate on the proliferation of osteoblasts isolated from rat bone marrow and osteoblastic cell line MC3T3-E1,"
Chulalongkorn University Dental Journal: Vol. 28:
Iss.
2, Article 5.
DOI: 10.58837/CHULA.CUDJ.28.2.5
Available at:
https://digital.car.chula.ac.th/cudj/vol28/iss2/5