Chulalongkorn University Dental Journal
Publication Date
2005-01-01
Abstract
Objective To evaluate the efficacy and safety of propofol intravenous infusion for conscious sedation in outpatients undergoing minor oral surgery in the Dental Hospital, Faculty of Dentistry, Chulalongkorn University. Materials and methods Fifty ASA physical status I or II patients, aged between 12 and 77 years, scheduled for minor oral surgery under local anesthesia were entered into the study. Intravenous sedation was accomplished by using propofol initial bolus of 0.75-1 mg/kg followed by the continuous infusion at a rate of 3 mg/kg/hr. The infusion rate was titrated to achieve and maintain an appropriate level of sedation. Vital signs: heart rate, blood pressure, respiratory rate, oxygen saturation and EKG were continuously monitored. The quality of sedation, degree of amnesia and patientsû satisfaction as well as the occurrence of side effects were assessed. Result The mean (SD) propofol intravenous bolus dose was 51.52 (11.35) mg (range 21-75 mg). The mean (SD) propofol infusion rate was 3.16 (0.58) mg/kg/hr (range 2.24-4.67 mg/kg/hr). The mean (SD) duration of sedation was 72.43 (32.03) minutes (range 17-150 minutes). The quality of sedation was assessed by the surgeons as satisfied 84% and adequate 16%. Number of patients reporting complete amnesia during injection of local anesthetics was 54%. There were no serious cardiovascular side effects, however, significant respiratory depression occurring after bolus propofol injection developed in one patient. Additional undesirable effects were pain during injection, increased talkativeness, pruritus and headache. Conclusion The continuous intravenous infusion of propofol may be an alternative to intravenous midazolam or nitrous oxide/oxygen for conscious sedation. It is safe provided that adequate patient monitoring and emergency care are available.
DOI
10.58837/CHULA.CUDJ.28.1.1
First Page
1
Last Page
10
Recommended Citation
Jirakijja, Jirawan; Changsirivatanathamrong, Vacharee; and Sombatpium, Kobsuke
(2005)
"Conscious sedation with propofol in outpatient oral surgery,"
Chulalongkorn University Dental Journal: Vol. 28:
Iss.
1, Article 1.
DOI: 10.58837/CHULA.CUDJ.28.1.1
Available at:
https://digital.car.chula.ac.th/cudj/vol28/iss1/1