•  
  •  
 

Chulalongkorn University Dental Journal

Publication Date

1982-01-01

Abstract

The median lethal dose (LD50) of local anaesthetics in mice was determined by the method of Reed & Muench. No statistical difference (P < 0.05) was found in comparing the (LD50) of the four commonly-used local anaesthetic preparations; they were lidocaine 2%, lidocaine 2% with adrenaline 1:80,000, lidocaine 2% with noradrenaline 1:50,000 and prilocaine 3% with felypressin 0.03 IU. It is suggested therefore that, in mice, the (LD50) of these local anaesthetics are comparable. However, lidocaine 2% with noradrenaline 1:50,000 had a wider therapeutic index, therefore it could be the safest local anaesthetic among the other three drugs.

DOI

10.58837/CHULA.CUDJ.15.1.2

First Page

9

Last Page

13

Included in

Dentistry Commons

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.